| http://www.w3.org/ns/prov#value | - While CD4+ T cells have long been considered to play a central role in the pathogenesis of RA, there is renewed interest in addressing the pivotal role of neutrophils in initiation, progression and maintenance of RA. Massive infiltration of neutrophils in the lesions releases the proinflammatory cytokines including TNF-??, IL-1 and IL-6, which can affect the functions of neutrophils and other infl
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