| http://www.w3.org/ns/prov#value | - The signal cascade that begins with an agonist binding to a TLR and is relayed through IRAK and TRAF6 eventually activates NF-??B, which stimulates transcription of various genes including those encoding cytokines such as TNF-??, IL-6, and IL-12. [0042] Many IRM compounds share a number of cellular activities, many of which are conserved across species, e.g., upregulation of co-stimulatory markers
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