| http://www.w3.org/ns/prov#value | - The prominent players in PDE4 development for cognitive enhancement to date have been Memory Pharmaceuticals and Helicon Pharmaceuticals; both companies developed drugs which advanced to Phase II testing for age-associated memory impairment, but neither drug met the requisite endpoint at moderate doses, and at higher doses ran into troublesome side effects such as nausea which have begun to be see
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