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  • The major cytokines in the inflammatory process are IL-1 and TNF-??.67,70 Both gram-positive and gram-negative bacteria can cause the release of these cytokines.69,70 IL-1 and TNF-?? initiate many events, including activation of the arachidonic acid cascade, production of acute-phase proteins in the liver, and induction of fever and intravascular coagulation.7,11,61 These cytokines also signal per
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