| http://www.w3.org/ns/prov#value | - The kappa opioid receptor antagonist of claim 8, wherein said compound is a compound of formula I: wherein X, Y, Z, n, m, j, k, and R9 are as stated; R1 is C2-8 alkyl, C3-8 alkenyl, C1-4 alkylaryl or a member selected from the following formulae: R2 is a member selected from the group consisting of formulae (a)-(i); R is hydrogen, C1-4 alkyl, C1-4 alkylaryl, or CO2R9; W is OH or OCOR9; R3 is hydro
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