| http://www.w3.org/ns/prov#value | - The blood CO level is determined by the sum of ambient and endogenous CO, the latter of which is derived from heme degradation catalyzed by HO.18 HO-1 is up-regulated by various stimuli, including hypoxia, oxidative stress, inflammatory cytokines, and some drugs, and plays a protective role in various pathologic conditions.19,20 Indeed, we have previously demonstrated the beneficial effects of HO-
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