| http://www.w3.org/ns/prov#value | - Therefore, the decision as to which antidepressant should be used is based on other factors, including history of prior response, adverse effects, concurrent medications, and cost.4 Classes of Antidepressants The monoamine hypothesis of depression states that depression is caused by a deficit in 1 or more of the following neurotransmitters: serotonin (5-HT), norepinephrine (NE), and/or dopamine (D
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