| http://www.w3.org/ns/prov#value | - 6-Chloronicotinoyl chloride analogs (10) are treated with the appropriate amine (R3R4NH) in the presence of base in an appropriate solvent, such as dichloromethane, acetonitrile, DMF, THF and the like, at a temperature from ???20??? C. to 120??? C. to form nicotinamides (11) as shown in Scheme III. Alternatively, 6-chloronicotinic acid analogs (12) may be coupled with the appropriate amine via an
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