| http://www.w3.org/ns/prov#value | - Alternatively, epigenetic inactivation of P-gpcan occur by DNA methylation at specific nucleotide sequences within the promotersequence, called CpG islands, as has been observed in some cancer tissues [80]; ordownregulation of P-gp can also occur by mechanisms other than by DNA methylation, forexample, in response to cobalamin, a vitamin B-12 derivative [50].Drug interactionsMany studies have char
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