| http://www.w3.org/ns/prov#value | - S-associated malignancies is thought to arise from the classic two-hit suppressor gene model: baseline heterozygosity secondary to germline PTCH mutation as the first hit, with the second hit due to mutagen exposure such as UV or ionizing radiation.[60,61,62,63,64] However, haploinsufficiency or dominant negative isoforms have also been implicated for the inactivation of PTCH1.[65]
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