| http://www.w3.org/ns/prov#value | - uch as transfection, electroporation, biolistics, naked DNA, plasmid, viral vector, liposomal delivery or other suitable means, or by administering a mutant SPL polypeptide) in a manner and for a time sufficient to obtain an immune system cell having the dominant negative SPL, results in competition for substrate (e.g., S1P) between wildtype (endogenous) SPL and the dominant negative mutant SPL, t
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