| http://www.w3.org/ns/prov#value | - Transforming growth factor (TGF??) prevents TH1 and TH2 differentiation and converts na??ve CD4 cells into Foxp3-expressing T regulatory (Treg) cell.1,2 In sharp contrast, in the presence of pro-inflammatory cytokines, including IL-6, TGF?? not only inhibits Foxp3 expression but also promotes the differentiation of pro-inflammatory IL17-producing CD4 effector T (TH17) cells.3???5
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