| http://www.w3.org/ns/prov#value | - Genetic and/or epigenetic deregulation of this pathway leads to aberrant nuclear accumulation of ??-catenin where it binds with T-cell factor-4 (TCF-4) to form a transcriptional complex [3]; this event drives gene expression such as c-Myc, cyclin D1, and EPCAM [4], [5], [6] that contributes to a malignant phenotype.
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