| http://www.w3.org/ns/prov#value | - es), ?? and ?? genes on chromosome 11 ?? thalassemia is often caused by single nucleotide substitutions; far less commonly, ?? thalassemia is caused by small insertions or deletions or other sequence variations of the ??-globin gene HBBOver 200 known mutations are categorized into 2 classes ?? zero (??0) No ??-globin chain synthesis from the affected allele?? plus (??+) Decreased ??-globin chain s
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