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  • es and 1 to 2% of idiopathic cases, making it the most common known genetic cause of PD. Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD.Methods: A sample, including 903 affected and 58 unaffected members from 509 f
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  • sanger.ac.uk