| http://www.w3.org/ns/prov#value | - Because CD4+ T cells are central in initiating and perpetuating the chronic autoimmune response in rheumatic diseases, many biologicals are aimed at interfering with T-cell activation and/or migration.A major advance in our understanding of T-cell activation has been the identification of the critical co-stimulatory molecules on T cells, such as CD28, lymphocyte function-associated antigen (LFA)-1
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