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  • Oestrogen receptor-positive disease comprises approximately 70% of cases and therapies targeting oestrogen synthesis or the ER are the most effective treatments, with adjuvant tamoxifen reducing the annual risk of recurrence and death by up to 47 and 26% respectively (Early Breast Cancer Trialists' Collaborative Group, 2005) and reducing the risk of contralateral disease by 50% (Fisher et al, 1998
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  • pubmedcentralcanada.ca