| http://www.w3.org/ns/prov#value | - ed in peripheral tissues such as skin,muscle, and (sometimes) lymphocytes.13However, inKufs disease the distribution of the pigment is much morerestricted.8,14,15Diagnosis is most reliably made by brainbiopsy, although sometimes the characteristic abnormali-ties can be found in neurons of the rectal mucosa or otherperipheral tissues.15,16Moreover, normal lipofuscin accu-mulates with age, and stric
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