| http://www.w3.org/ns/prov#value | - er inthe muscles from the knockout mice,49confirming theproposed role of AMPK in maintenance of cellular energyhomeostasis.In many tissues and organs, such as the heart, the AMPKsystem may be significantly activated by hypoxia only duringpathological ischemic episodes, but there is evidence that, incertain specialized oxygen-sensing cells, the system is impor-tant in the response to more physiolog
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