| http://www.w3.org/ns/prov#value | - The cytokines involved, including IL-1 and TNF-??, have direct and indirect pro-inflammatory effects to regulate the degradation of ECM components by stimulating secretion of proteolytic enzymes and other mediators, such as MMPs, aggrecanases and other members of the 'a disintegrin and metallo-proteinase with thrombospondin motifs' (ADAMTS) gene family, NO, and prostaglandin E2 [149,177,178].
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