| http://www.w3.org/ns/prov#value | - Bone destruction and osteoporosis are accelerated in chronic inflammatory diseases, such as rheumatoid arthritis (RA) and periodontitis, in which many studies have shown the proinflammatory cytokines, especially TNF??, play an important role; TNF?? causes osteoclast-induced bone destruction as well as the inhibition of osteoblastogenesis.
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