| http://www.w3.org/ns/prov#value | - a) contacting a cell expressing a polypeptide encoded by an essential gene selected from the group consisting of the essential genes corresponding to SEQ ID NO. 3, 7, 39, 48, 55-58, 69 and 70, 77, 78, 82, and 84 with a test compound; and b) determining whether the amount or level of activity of said polypeptide is altered; wherein an alteration in said amount or level of activity of said polypepti
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