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  • Take leucovorin exactly as prescribed by your doctor.What SPECIAL PRECAUTIONS should I follow?Before taking trimetrexate, tell your doctor and pharmacist if you are allergic to trimetrexate or any other drugs.tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially acetaminophen (Tylenol), aspirin, clotrimazole (Mycelex), erythromycin, fluconazol
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