| http://www.w3.org/ns/prov#value | - date, and it offers reassurance that, as a group, PPIs do not seem to increase the overall risk of birth defects when taken anytime in pregnancy, and particularly during the first trimester, the period when most birth defects develop, he told Reuters Health in an e-mail.Still, the study wasn't large enough to rule out an effect of individual drugs on different birth defects, such as cleft lip or h
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