| http://www.w3.org/ns/prov#value | - With respect to cartilage damage, TNF also is an inducer of matrix enzymes such as aggrecanases and metalloproteinases, particularly MMP-1, MMP-2, and MMP-3, which are produced by synovial fibroblasts, neutrophils, and chondrocytes and degrade the cartilage matrix.
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