| http://www.w3.org/ns/prov#value | - We found that after binding of the HIV-1 envelope protein gp120 to the dendritic cell surface protein DC-SIGN, the subsequent activation by CD40 ligation, or by exposure to bacterial product lipopolysaccharide or pro-inflammatory cytokines such as TNF-?? and IL-1??, will lead to overexpression of pro-apoptotic molecule ASK-1, resulting in excessive dendritic cell death.
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