| http://www.w3.org/ns/prov#value | - These diseases can be sporadic, familial, or acquired by infection, and the common hallmark is a distinct pathology in the central nervous system (CNS) characterized by neuronal loss, spongiform degeneration, and gliosis (38, 46).Expression of the host-encoded cellular PrP (PrPC) is fundamental for the onset of disease since PrP-deficient mice are refractory to TSE infection (11, 31).
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