| http://www.w3.org/ns/prov#value | - The PKC pathway acts upstream of PGI2S, and PKC can also activate platelets via other signaling proteins, including MAPK. PKA, PKC, PTGIR and MAPK mRNA expression were analyzed by qRT-PCR. The expression levels of all of these signaling molecules, except for MAPK, were up-regulated in HUVEC-PGI2S cells compared to HUVEC-mock cells, and even higher in HUVEC-PGI2S-tPA cells (Figure 4A).
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