| http://www.w3.org/ns/prov#value | - (mammalian target of rapamycin) protein kinase is found in two complexes in eukaryotes: mTORC1, which integrates nutrient and hormonal regulation of protein synthesis and cell growth, and mTORC2, which phosphorylates Akt on Ser473 and plays a role in actin cytoskeletal rearrangements (Sarbassov et al., 2005 ; Wullschleger et al., 2006 ). mTORC1 activity is stimulated by growth factors such as ins
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