| http://www.w3.org/ns/prov#value | - Impaired drug transport is mediated by multidrug resistance-related proteins and energy-dependent efflux pumps such as P-glycoprotein, which cause a decrease in drug accumulation.[23] Drug detoxification occurs mainly in response to alkylating agents and is mediated via increase of the glutathione S-transferase activity that causes inactivation of dacarbazine.[19] Studies targeting these factors h
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