| http://www.w3.org/ns/prov#value | - A central player of this effect has been identified by TOR pathway: when the cell cycle is blocked but mTOR is still active, it causes hypertrophic, hyperactive, hyperfunctional phenotype, with compensatory resistance to signals such as insulin and growth factors, switching quiescence into senescence; therefore, TOR limits life span by accelerating age-related diseases [125].
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