| http://www.w3.org/ns/prov#value | - sodium, hypernatremia and hypovolemia. 4.3 Hypovolemic hyponatremia Risks associated with worsening hypovolemia, including complications such as hypotension and renal failure, outweigh possible benefits. 4.4 Concomitant use of strong CYP 3A inhibitors Ketoconazole 200 mg administered with tolvaptan increased tolvaptan exposure by 5???fold.
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