| http://www.w3.org/ns/prov#value | - h DHFR* integrationTo study formation and structure of amplicons, we took advantage of the fact that resistance to methotrexate can be accomplished by a number of mechanisms, including copy number gain or amplification of DHFR and loss or down regulation of the folate transporter, SLC19A1 on chromosome 21 [15,16].
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