| http://www.w3.org/ns/prov#value | - Studies in human adipocytes indicate that PAI-1 synthesis is upregulated by insulin, glucocorticoids, angiotensin II, some fatty acids and, most potently, by cytokines such as TNF-?? and transforming growth factor-??, whereas catecholamines reduce PAI-1 production [36, 37].The PAI-1 is a protein involved in fibrinolysis and is altered in obesity [38].
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