| http://www.w3.org/ns/prov#value | - Direct target gene regulation by HIF???1. (a) HIF???1 binds to a HRE near a protein???coding gene (CDS) and recruits coactivators such as p300 to activate transcription. (b) In rare cases, HIF???1 binding may lead to transcriptional repression, which is likely to involve recruitment of corepressors, possibly in concert with repressors.
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