| http://www.w3.org/ns/prov#value | - However, inhibitors binding to the N terminus of Hsp90 can restore this function and reactivate CHIP or other E3 ligases, such as Parkin and Cullin 5, toward aberrant clients, leading to their proteasomal degradation and cellular depletion (Whitesell et al., 1994; Xu et al., 2002; Trepel et al., 2010).
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