| http://www.w3.org/ns/prov#value | - However, the chondrocytes not only secrete the proteinases responsible of cartilage destruction, but they also produce proinflammatory cytokines such as IL-1 and TNF-??, creating an inflammatory environment that also favours increased synthesis of proteinases [17] (Figure ???(Figure2a2a).The destruction of the ECM in OA results from several events that take place in sequence.
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