| http://www.w3.org/ns/prov#value | - This observation, corroborated by the description of a similar phenotype caused by mutations in CD40 (15), has demonstrated an essential role for the CD40 signaling pathway in B cells for both CSR and SHM.Other Ig CSR deficiencies are a consequence of an intrinsic defect of the CSR machinery (16, 17).
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