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http://webisa.webdatacommons.org/86008233
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The text says that drugs such as quinine or piperine could 'potentially allow loperamide to cross the blood-brain barrier' i.e. be active in the brain for long enough to work before the p-glycoprotein efflux pump removes them.
http://www.w3.org/ns/prov#wasQuotedFrom
drugs-forum.com