| http://www.w3.org/ns/prov#value | - IL-1ra is also produced by hepatocytes and is a major component of the acute phase proteins produced in the liver and secreted into the circulation to regulate immune and inflammatory responses. [0203] The IL-1 signaling complex activates several intracellular signal transduction pathways, including the activities of NF-??B and AP-1 described above.
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