| http://www.w3.org/ns/prov#value | - Although excess uptake of water through AQP4 on astrocyte endfeet can lead to cytotoxic edema [135, 157, 264], the loss of astrocytes or the failure of astrocyte AQP4 channels can also lead to vasogenic edema or accumulation of extracellular fluid [33, 157, 177, 264].Blood brain barrier integrityIntegrity of the BBB is lost after many types of CNS insults including trauma and stroke.
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