| http://www.w3.org/ns/prov#value | - within tumors. (3) TAMs are retained in hypoxic/necrotic areas due to abrogation of chemotactic signal transduction, down-regulation of chemoattractant receptors, and possibly the migration inhibitory actions of MIF. (4) Once in hypoxic areas, TAMs are induced to express VEGF, which amplifies the attraction of TAMs to the area, and other factors that promote angiogenesis and tumor progression.
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