| http://www.w3.org/ns/prov#value | - For commercial re-use, please contact journals.permissions/at/oupjournals.orgThis article has been cited by other articles in PMC.AbstractKey amino acid positions that are important for maintaining the 3D structure of a protein and/or its function(s), e.g. catalytic activity, binding to ligand, DNA or other proteins, are often under strong evolutionary constraints.
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