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  • Phenoxybenzamine, a nonselective, noncompetitive, long-acting ??-adrenergic blocker for many years, has been a mainstay of therapy. [1],[9],[10],[11],[12],[13],[14] Phenoxybenzamine acts on ??-adrenergic receptors, causing alkylation of receptor's complex by a reactive carbonium ion. [11],[12] Persistent hypotension and peripheral edema are the most common side effects.
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