• The ectopic expression of EGLN2 under 21% oxygen did not result in further diminution of HIF-target gene expression (data not shown), which is likely due to the fact that endogenous EGLN2 is highly abundant or that every available EGLN2 is already activated under hyper-oxygenated conditions.HIF-regulated genes are involved in many physiological processes including angiogenesis, metabolism, cell pr