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  • To design a sustained release dosage form, the minimum absorption rate constant should be lower than 0.25 hr -1 to 0.35 hr -1 is necessary for 95% of the administered dose to be absorbed .Slide 4: Distribution: The distribution of drug is into tissue is an important factor since it not only lowers the concentration of circulating drug but also can be rate limiting with blood and extracellular flui
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