| http://www.w3.org/ns/prov#value | - Another embodiment of the present invention is a pharmaceutical composition comprising a gap-widened antisense oligonucleotide 18-24 nucleotides in length comprising: a gap region having greater than 11 contiguous 2???-deoxyribonucleotides; and a first wing region and a second wing region flanking the gap region, wherein each of said first and second wing regions independently have 1 to 8 2???-O-(
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