| http://www.w3.org/ns/prov#value | - This region, which contains the catalytic domain, is required for cellular transformation,16 whereas the N-terminal fusion partners act as dimerizing domains.17,18 Activated ALK chimeras bind multiple adaptor proteins such as Grb2, Shc, IRS-1, and p130Cas, which link them to diverse pathways regulating cell proliferation, survival, and cell transformation.
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