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  • Unlike other PIs, epoxyketones show potent selectivity to the proteasome, without inhibitory effects on other proteases such as calpain, trypsin, papain, chymotrypsin and cathepsins [31], due to the fact that epoxyketone moiety can form a morpholino adduct with the active site amino terminal Thr of the ??5 subunit [32].
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