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  • The idea that drugs of abuse act via the endogenous reward systems in the brain first arose when psychostimulants such as amphetamine and cocaine have been found to alter support intracranial self-stimulation thresholds.??? 26. sorif said... on Apr 10, 2015 at 07:21AM ???Dopamine and norepinephrine are very crucial neurotransmitters whose functions can never be underestimated.
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